Febuxostat 40mg Tablet is a uric acid–lowering medication primarily used for the long-term management of gout and hyperuricemia (high uric acid levels).

It helps prevent painful gout attacks, joint inflammation, and crystal deposition by reducing the production of uric acid in the body.

Febuxostat 40mg Tablet

Summary

Febuxostat 40mg Tablet is a uric acid–lowering medication primarily used for the long-term management of gout and hyperuricemia (high uric acid levels).

It helps prevent painful gout attacks, joint inflammation, and crystal deposition by reducing the production of uric acid in the body.

Febuxostat is especially beneficial for patients who cannot tolerate allopurinol or require more effective uric acid control.

Uses of Febuxostat 40mg Tablet

Treatment of chronic gout
Reduction of high blood uric acid levels (hyperuricemia)
Prevention of gout flare-ups
Prevention of urate crystal deposition in joints
Long-term management of gout-related arthritis

Key Benefits

Effectively Lowers Uric Acid: Helps maintain uric acid within target range
Prevents Gout Attacks: Reduces frequency and severity of flare-ups
Protects Joints: Prevents crystal buildup and joint damage
Suitable Alternative: Useful for patients intolerant to allopurinol
Once-Daily Dosing: Improves treatment compliance

How to Use

Take once daily or as prescribed by your doctor
Can be taken with or without food
Swallow whole with water
Continue therapy even if gout attacks occur initially

Important: Febuxostat is for long-term uric acid control, not for treating acute gout pain.

How It Works

Febuxostat works by inhibiting xanthine oxidase, an enzyme responsible for producing uric acid in the body.

By blocking this enzyme, Febuxostat reduces uric acid formation, lowering blood urate levels and preventing crystal deposition in joints and tissues.

Side Effects

Common (usually mild):

Nausea
Headache
Joint pain during early treatment
Mild liver enzyme elevation
Skin rash

Rare but Serious (seek medical help):

Severe allergic reactions
Chest pain or heart-related symptoms
Severe liver problems (yellowing of eyes/skin)
Worsening gout attacks initially

Safety Advice

Acute Gout Attack: Do not start during an active severe attack unless advised
Heart Disease: Use with caution; inform your doctor
Liver Disease: Regular liver function monitoring recommended
Kidney Disease: Usually safe; dose adjustment rarely required
Hydration: Drink plenty of water to help uric acid excretion

Pregnancy & Breastfeeding

Pregnancy: Not recommended unless clearly necessary
Breastfeeding: Avoid or use only under medical advice

Drug Interactions

Azathioprine
Mercaptopurine
Theophylline
Certain chemotherapy drugs

Combining these may cause serious side effects.

Food & Lifestyle Advice

Limit alcohol intake (especially beer)
Reduce high-purine foods (red meat, seafood, organ meats)
Maintain healthy weight
Stay well hydrated

Storage

Store below 25°C
Protect from moisture and direct sunlight
Keep out of reach of children
Do not use after expiry date

References

https://www.drugs.com/febuxostat.html
https://medlineplus.gov/druginfo/meds/a609020.html
https://www.ncbi.nlm.nih.gov/books/NBK482344/
https://pubmed.ncbi.nlm.nih.gov/19793445/
https://www.ema.europa.eu/en/medicines/human/EPAR/adenuric