Sitagliptin 50mg + Metformin 500mg Tablet is a combination oral anti-diabetic medicine used in the management of Type 2 diabetes mellitus. It combines two effective blood sugar-lowering agents that work through different mechanisms to improve glycemic control. This medicine helps control both fasting and post-meal blood sugar levels and reduces the risk of diabetes-related complications when used along with diet and exercise.

Sitagliptin 50mg + Metformin 500mg Tablet

Summary:

Sitagliptin 50mg + Metformin 500mg Tablet is a combination oral anti-diabetic medicine used in the management of Type 2 diabetes mellitus. It combines two effective blood sugar-lowering agents that work through different mechanisms to improve glycemic control. This medicine helps control both fasting and post-meal blood sugar levels and reduces the risk of diabetes-related complications when used along with diet and exercise.

Uses:

Management of Type 2 diabetes mellitus
Improvement of blood sugar control in adults
Combination therapy when single-drug treatment is insufficient
Reduction of risk of long-term diabetic complications

Key Benefits:

Provides dual-action blood sugar control
Helps lower fasting and post-meal glucose levels
Low risk of hypoglycemia compared to some other diabetes medicines
May help with weight control (due to Metformin component)
Convenient fixed-dose combination improves treatment compliance

Dosage Instructions:

Take strictly as prescribed by your doctor.
Usually taken once or twice daily depending on blood sugar levels.
Best taken with meals to reduce stomach upset (due to Metformin).
Swallow the tablet whole with water.
Do not skip doses or stop suddenly without medical advice.

How It Works:

Sitagliptin inhibits the DPP-4 enzyme, increasing incretin hormone levels, which stimulate insulin release and reduce excess glucose production.
Metformin reduces glucose production in the liver and improves the body’s sensitivity to insulin.

Together, they help maintain stable blood sugar levels throughout the day.

Side Effects:

Common Side Effects:

Nausea
Diarrhea
Stomach discomfort
Headache
Upper respiratory tract infection

Serious (Rare) Side Effects:

Lactic acidosis (rare but serious, related to Metformin)
Severe abdominal pain (possible pancreatitis)
Allergic reactions
Vitamin B12 deficiency (with long-term use)

Seek immediate medical help if you experience severe weakness, breathing difficulty, or persistent abdominal pain.

Safety Advice:

Alcohol: Avoid excessive alcohol consumption as it increases the risk of lactic acidosis.
Kidney Disease: Dose adjustment may be required. Not recommended in severe kidney impairment.
Liver Disease: Use cautiously under medical supervision.
Pregnancy & Breastfeeding: Use only if prescribed by a doctor.
Driving: Be cautious if combined with other medicines that may cause low blood sugar.

References:

https://www.ncbi.nlm.nih.gov/books/NBK430801/
https://www.ncbi.nlm.nih.gov/books/NBK518983/
https://medlineplus.gov/druginfo/meds/a606023.html
https://medlineplus.gov/druginfo/meds/a696005.html
https://www.fda.gov/drugs